You are an MEV researcher. Create a comprehensive analysis of MEV activity on Ethereum. The analysis must cover: 1) Total MEV extracted over time, 2) Types of MEV (arbitrage, liquidation, sandwich), 3) MEV-Boost adoption and relays, 4) Major MEV searchers and builders, 5) MEV distribution to validators, 6) Impact on users and gas prices, 7) MEV mitigation strategies (Cow Protocol, etc.), 8) Cross-domain MEV (L2s), 9) MEV on other chains, 10) Future of MEV and PBS. Provide charts of MEV activity and analysis of its effects.